Recon
← Peptides

KPV

Animal-only

Lysine-Proline-Valine · Lys-Pro-Val · alpha-MSH (11-13) · α-MSH (11-13)

Limited evidence: the strongest curated study is Animal-only — no human-trial data found as of 2026-06-04. State this honestly.

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Chemical & identity

Molecular formula
C16H30N4O4
Molecular weight
342.43 g/mol · PubChem
PubChem CID
125672 · PubChem
SMILES
CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N
InChIKey
YSPZCHGIWAQVKQ-AVGNSLFASA-N
Category
Anti-inflammatory

Chemical/structural fields are auto-pulled and source-linked.

Mechanism (curated)

No established mechanism of action has been curated yet.

Research

  • Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.

    Animal-only

    Xiao B et al. · Molecular therapy : the journal of the American Society of Gene Therapy · 2017 · Animal study

    This study evaluated hyaluronic acid-functionalized nanoparticles loaded with KPV (lysine-proline-valine), a tripeptide shown to reduce inflammatory responses in colonic cells, for treating ulcerative colitis. In an animal model (mouse), oral administration of HA-KPV-NPs encapsulated in a chitosan/alginate hydrogel demonstrated superior efficacy compared to KPV-NP/hydrogel without hyaluronic acid functionalization, including reduced TNF-α expression and better prevention of mucosal damage. The nanoparticles were designed to target colonic epithelial cells and macrophages, showed appropriate size and charge properties, and appeared nontoxic to intestinal cells in vitro. The results suggest the delivery system enables KPV internalization into target cells and exerts combined effects on mucosal healing and inflammation reduction.

    DOIPubMed 28143741Free full text (cc-by-nc-nd)

Summaries are our own; we link to originals (PubMed / DOI) and never rehost full text.

Regulatory status

FDA approved
No
WADA prohibited
No
Notes
Operator review required.

Legal/regulatory status varies by jurisdiction and changes over time — accurate as of last review (2026-06-04).

Data sources: Curated IDs (PubChem/UniProt/ChEMBL) + Europe PMC + ClinicalTrials.gov (2026-06-04).

Last reviewed 2026-06-04

Research/informational use only; not medical advice. Legal status varies by jurisdiction and changes over time — any status note is dated.